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Literature summary extracted from

  • Hosokawa, N.; You, Z.; Tremblay, L.O.; Nagata, K.; Herscovics, A.
    Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases (2007), Biochem. Biophys. Res. Commun., 362, 626-632.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.209 overexpressed in HEK-293 cells Homo sapiens
3.2.1.209 overexpressed in HEK-293 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.209 kifunensine inhibits Golgi alpha1,2-mannosidase. Addition of kifunensine completely inhibits mannose trimming from alpha1-antitrypsin null (Hong Kong) in mock transfected cells. Kifunensine inhibits alpha1-antitrypsin null (Hong Kong) degradation in cells co-transfected with the Golgi mannosidases Homo sapiens
3.2.1.209 kifunensine inhibits Golgi alpha1,2-mannosidase. Addition of kifunensine completely inhibits mannose trimming from alpha1-antitrypsin null (Hong Kong) in mock transfected cells. Kifunensine inhibits alpha1-antitrypsin null (Hong Kong)degradation in cells co-transfected with the Golgi mannosidases; inhibits Golgi alpha1,2-mannosidase. Addition of kifunensine completely inhibits mannose trimming from alpha1-antitrypsin null (Hong Kong) in mock transfected cells. Kifunensine inhibits alpha1-antitrypsin null (Hong Kong)degradation in cells co-transfected with the Golgi mannosidases Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.209 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.2.1.209 Golgi apparatus
-
 Homo sapiens 5794
-
3.2.1.209 Golgi apparatus
-
 Mus musculus 5794
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.209 alpha1-antitrypsin null + H2O Homo sapiens
-
 ? + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O Mus musculus
-
 ? + D-mannose
-
 ?
3.2.1.209 additional information Homo sapiens generating the signal that targets misfolded glycoproteins for endoplasmic reticulum-associated protein degradation (ERAD) ?
-
 ?
3.2.1.209 additional information Mus musculus generating the signal that targets misfolded glycoproteins for endoplasmic reticulum-associated protein degradation (ERAD) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.209 Homo sapiens
-
-
-
3.2.1.209 Mus musculus P39098
-
-
3.2.1.209 Mus musculus P45700
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Homo sapiens ? + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Mus musculus ? + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Homo sapiens alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Mus musculus alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Homo sapiens alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Mus musculus alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Homo sapiens alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Mus musculus alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Homo sapiens alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O
-
 Mus musculus alpha-D-mannopyranosyl-(1,2)-alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O overexpression of each Golgi alpha1,2-mannosidase enhances alpha1-antitrypsin null degradation and trimming of its N-glycans to alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose Homo sapiens alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 alpha1-antitrypsin null + H2O overexpression of each Golgi alpha1,2-mannosidase enhances alpha1-antitrypsin null degradation and trimming of its N-glycans to alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose Mus musculus alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,3)-[alpha-D-mannopyranosyl-(1,6)]-alpha-D-mannopyranosyl-(1,6)]-beta-D-mannopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1,4)-2-(acetylamino)-2-deoxy-beta-D-glucopyranose + D-mannose
-
 ?
3.2.1.209 additional information generating the signal that targets misfolded glycoproteins for endoplasmic reticulum-associated protein degradation (ERAD) Homo sapiens ?
-
 ?
3.2.1.209 additional information generating the signal that targets misfolded glycoproteins for endoplasmic reticulum-associated protein degradation (ERAD) Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.209 ER alpha1,2-mannosidase I
-
 Homo sapiens
3.2.1.209 Golgi alpha1,2-mannosidase IA generating the signal that targets misfolded glycoproteins for endoplasmic reticulum-associated protein degradation (ERAD) Mus musculus
3.2.1.209 Golgi alpha1,2-mannosidase IB generating the signal that targets misfolded glycoproteins for endoplasmic reticulum-associated protein degradation (ERAD) Mus musculus
3.2.1.209 Golgi alpha1,2-mannosidase IC
-
 Homo sapiens