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Literature summary extracted from

  • Canault, M.; Leroyer, A.S.; Peiretti, F.; Leseche, G.; Tedgui, A.; Bonardo, B.; Alessi, M.; Boulanger, C.M.; Nalbone, G.
    Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1 (2007), Am. J. Pathol., 171, 1713-1723.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 TIMP-3 85% inhibition at 10 nM Homo sapiens
3.4.24.86 TMI-2 complete inhibition at 50 nM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 artery atherosclerotic plaque Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 protein C receptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 tumour necrosis factor receptor-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 tumour necrosis factor receptor-2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.86 ADAM-17
-
 Homo sapiens
3.4.24.86 TACE
-
 Homo sapiens
3.4.24.86 TNF-alpha converting enzyme
-
 Homo sapiens
3.4.24.86 tumor necrosis factor-alpha converting enzyme
-
 Homo sapiens