Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Woodard, G.E.; Zhao, J.; Rosado, J.A.
    Different effect of ATP on ANP receptor guanylyl cyclase in spontaneously hypertensive and normotensive rats (2006), Acta Physiol. (Oxf.), 188, 195-206.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 ATP induces a concentration-dependent increase in basal and atrial natriuretic peptide 1-28-stimulated GC activity of glomerular and papillary membranes that is significantly higher in spontaneously hypertensive rats than in age-matched Wistar Kyoto rats Rattus norvegicus
4.6.1.2 ATPgammaS is more effective than ATP on glomerular and papillary membranes, has little effect on GC activity in solubilized membranes Rattus norvegicus
4.6.1.2 atrial natriuretic peptide 1-28 increases GC enzymatic activity of glomerular and papillary membranes in a concentration-dependent manner Rattus norvegicus

Application

EC Number Application Comment Organism
4.6.1.2 additional information differences in the effects of ATP on signal transduction of GC-coupled natriuretic peptide receptor A between Wistar Kyoto and spontaneously hypertensive rats Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 ATP in solubilized membranes ATP exerts an inhibitory role on basal and atrial natriuretic peptide 1-28-induced GC activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.2 0.4077
-
 GTP Wistar Kyoto rats, in presence of atrial natriuretic peptide 1-28 and ATP in glomerular membranes Rattus norvegicus
4.6.1.2 0.5597
-
 GTP Wistar Kyoto rats, in presence of atrial natriuretic peptide 1-28 in glomerular membranes Rattus norvegicus
4.6.1.2 0.667
-
 GTP Wistar Kyoto rats, in presence of ATP in glomerular membranes Rattus norvegicus
4.6.1.2 0.8234
-
 GTP Wistar Kyoto rat, basal GC activity of glomerular membranes Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 membrane glomerular and papillary membranes Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.2 Mg2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Rattus norvegicus
-
 Wistar Kyoto and spontaneously hypertensive rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?