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Literature summary extracted from

  • Oefner, C.; Pierau, S.; Schulz, H.; Dale, G.E.
    Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV (2007), Acta Crystallogr. Sect. D, 63, 975-981.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 MCB3937
-
Homo sapiens
3.4.24.11 MCB3937 bifunctional inhibitor of NEP and DPP-IV Homo sapiens
3.4.24.11 MCB4241 bifunctional inhibitor of NEP and DPP-IV Homo sapiens
3.4.24.11 thiorphan
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens
-
-
-
3.4.24.11 Homo sapiens P08473
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 DPP-IV
-
Homo sapiens
3.4.24.11 CALLA
-
Homo sapiens
3.4.24.11 CD10
-
Homo sapiens
3.4.24.11 enkephalinase
-
Homo sapiens
3.4.24.11 NEP
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.11 0.000004
-
thiorphan
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.14.5 0.0003
-
-
Homo sapiens MCB3937
3.4.24.11 0.00045
-
-
Homo sapiens MCB3937
3.4.24.11 0.0006
-
-
Homo sapiens MCB4241