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Literature summary extracted from

  • Chen, X.; Zhang, J.; Baker, S.M.; Chen, G.
    Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) (2007), Toxicology, 231, 224-233.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.2 additional information methotrexate and 6-(4-chlorophenyl)imidazo [2,1-b][1,3] thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime induction of hSULT2A1 through interacting with androstane receptor and retinoid X receptor alpha mediated by the IR2 element, mechanism, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.2 SULT2A1, expression in Caco-2 cells and analysis of the transcriptional regulation mechanism of hSULT2A1 promoter, quantitative enzyme expression analysis. Constitutive androstane receptor and retinoid X receptor alpha are involved in the transcriptional regulation of hSULT2A1, overview Homo sapiens
2.8.2.15 cloning of 5'-flanking region of SULT2A1 and expression of a SULT2A1-reporter construct in Caco-2 cells, transcriptional regulation mechanism analysis, co-expression of human nuclear receptors constitutive androstane receptor CAR and retinoid X receptor alpha RXRalpha which are involved in the regulation, electrophoretic mobility shift assay for interaction study, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.2 additional information SULT2A1 downreguletion by siRNA, and progressive promoter deletion, expression analysis. An IR2 element of the hSULT2A1 promoter region mediates the methotrexate induction of hSULT2A1 through interacting with androstane receptor and retinoid X receptor alpha Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.2 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + dehydroepiandrosterone Homo sapiens the sulfation, catalyzed by SULT, is important in the regulation of biological activities of hormones and neurotransmitters, the metabolism of drugs, and the detoxification of xenobiotic toxicants. Sulfation also leads to the bioactivation of procarcinogens. Human SULT2A1 is a major sulfotransferase catalyzing the sulfation of hydroxysteroids and xenobiotic alcohols, mechanisms controlling the regulation of hSULT2A1, overview adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
2.8.2.15 additional information Homo sapiens the nuclear receptors constitutive androstane receptor CAR and retinoid X receptor alpha RXRalpha are involved in regulation of SULT2A1 enzyme expression, regulation mechanism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens Q06520
-
-
2.8.2.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + dehydroepiandrosterone the sulfation, catalyzed by SULT, is important in the regulation of biological activities of hormones and neurotransmitters, the metabolism of drugs, and the detoxification of xenobiotic toxicants. Sulfation also leads to the bioactivation of procarcinogens. Human SULT2A1 is a major sulfotransferase catalyzing the sulfation of hydroxysteroids and xenobiotic alcohols, mechanisms controlling the regulation of hSULT2A1, overview Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + dehydroepiandrosterone i.e. PAPS and DHEA Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?
2.8.2.15 additional information the nuclear receptors constitutive androstane receptor CAR and retinoid X receptor alpha RXRalpha are involved in regulation of SULT2A1 enzyme expression, regulation mechanism, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 dehydroepiandrosterone sulfotransferase
-
 Homo sapiens
2.8.2.2 SULT2A1
-
 Homo sapiens
2.8.2.15 dehydroepiandrosterone sulfotransferase
-
 Homo sapiens
2.8.2.15 SULT2A1
-
 Homo sapiens