EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.6.5.2 | Clofibrate | administration to animals for 5 to 10 days, increase in enzyme protein and activity | Mus musculus | |
1.6.5.2 | Clofibrate | administration to animals for 5 to 10 days, increase in enzyme protein and activity | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.6.5.2 | medicine | acetaminophen is bioactivated by cytochrome P450 to the reactive intermediate N-acetyl-p-benzoquinone imine. Enhanced levels of hepatic enzyme may detoxify N-acetyl-p-benzoquinone imine by reducing it back to acetaminophen | Homo sapiens |
1.6.5.2 | medicine | clofibrate-mediated hepatoprotection against acetaminophen does not appear to be dependent upon enhanced expression of enzyme. Conditions of 94% inhobition of enzyme do not increase the susceptibility of hepatocytes from clofibrate treated mice to acetaminophen | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.5.2 | Homo sapiens | - |
recombinant isoform NQO1 | - |
1.6.5.2 | Mus musculus | - |
- |
- |
1.6.5.2 | Mus musculus CD-1 | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.5.2 | acetaminophen + NAD(P)H + H+ | - |
Homo sapiens | N-acetyl-p-benzoquinone imine + NAD(P)+ | enhanced levels of hepatic enzyme may detoxify N-acetyl-p-benzoquinone imine by reducing it back to acetaminophen | r |