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Literature summary extracted from

  • Billaut-Laden, I.; Allorge, D.; Crunelle-Thibaut, A.; Rat, E.; Cauffiez, C.; Chevalier, D.; Houdret, N.; Lo-Guidice, J.M.; Broly, F.
    Evidence for a functional genetic polymorphism of the human thiosulfate sulfurtransferase (rhodanese), a cyanide and H2S detoxification enzyme (2006), Toxicology, 225, 1-11.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.8.1.1 E102D natural polymorphism, slight decrease both in Vmax and Km value Homo sapiens
2.8.1.1 additional information identification of eleven polymorphisms in 50 unrelated French individuals with Caucasian origin. Six polymorphisms lead to a significant decrease in promoter activity Homo sapiens
2.8.1.1 P285A natural polymorphism, ratio of Vmax to Km value is decreased by 50% Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.1.1 2.5
-
 thiosulfate mutant E102D, 30°C, pH 5.0 Homo sapiens
2.8.1.1 3.4
-
 thiosulfate wild-type, 30°C, pH 5.0 Homo sapiens
2.8.1.1 4.8
-
 thiosulfate mutant P285A, 30°C, pH 5.0 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.1 Homo sapiens
-
 identification of functional genetic polymorphisms
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.1 thiosulfate + cyanide
-
 Homo sapiens sulfite + thiocyanate
-
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