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Literature summary extracted from

  • Hanrahan, J.W.; Wioland, M.A.
    Revisiting cystic fibrosis transmembrane conductance regulator structure and function (2004), Proc. Am. Thorac. Soc., 1, 17-21.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.6.1.6 additional information CFTR is a an ATP-dependent chloride channel, tightly regulated by phosphorylation, two distinct gating modes with one dependent on hydrolysis and the other requiring only stable ATP binding Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
5.6.1.6 G551D channel does not open in response to phosphorylation by protein kinase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.6 membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.1.6 Mg2+ needed for ATP hydrolysis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.6
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.6 intestine
-
 Rattus norvegicus
-
5.6.1.6 additional information in secretory serous cells of the submucosal glands of the airway Rattus norvegicus
-
5.6.1.6 pancreatic duct
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel ATPase activity is much higher at NBD1 than NBD2 of CFTR, ATPase activity is not strictly required for its channel activity Rattus norvegicus ADP + phosphate + open Cl- channel
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Rattus norvegicus
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Rattus norvegicus