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Literature summary extracted from
- Mechanism-based inactivators of plant copper/quinone containing amine oxidases (2005), Phytochemistry, 66, 1751-1758.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.21 | 1,2-Diaminoethane | - |
Lens culinaris |  |
| 1.4.3.21 | 1,4-diamino-2-butyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | 1,4-diamino-2-butyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | 1,4-diamino-2-butyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | 1,4-diamino-2-butyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | 1,5-diamino-2-pentyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | 1,5-diamino-2-pentyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | 1,5-diamino-2-pentyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | 1,5-diamino-2-pentyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | 2-Bromoethylamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | 2-Bromoethylamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | 2-Bromoethylamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | 2-Bromoethylamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | 2-chloroethylamine | - |
Lens culinaris | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | tryptamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | tryptamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | tryptamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | tryptamine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
| 1.4.3.21 | tyramine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lathyrus sativus | |
| 1.4.3.21 | tyramine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | |
| 1.4.3.21 | tyramine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Onobrychis viciifolia | |
| 1.4.3.21 | tyramine | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Pisum sativum | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.21 | 0.5 | - |
tryptamine | - |
Lens culinaris | |
| 1.4.3.21 | 0.71 | - |
tyramine | - |
Lens culinaris | |
| 1.4.3.21 | 1 | - |
1,4-diamino-2-butyne | - |
Pisum sativum | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.21 | Cu2+ | - |
Lens culinaris | |
| 1.4.3.21 | Cu2+ | - |
Onobrychis viciifolia | |
| 1.4.3.21 | Cu2+ | - |
Pisum sativum | |
| 1.4.3.21 | Cu2+ | - |
Lathyrus sativus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.4.3.21 | Lathyrus sativus | Q6A174 | fragment | - |
| 1.4.3.21 | Lens culinaris | - |
- |
- |
| 1.4.3.21 | Onobrychis viciifolia | - |
- |
- |
| 1.4.3.21 | Pisum sativum | Q43077 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.4.3.21 | additional information | topaquinone is derived by post-translational modification of a conserved tyrosine residue in the protein chain | Lens culinaris |
| 1.4.3.21 | additional information | topaquinone is derived by post-translational modification of a conserved tyrosine residue in the protein chain | Onobrychis viciifolia |
| 1.4.3.21 | additional information | topaquinone is derived by post-translational modification of a conserved tyrosine residue in the protein chain | Pisum sativum |
| 1.4.3.21 | additional information | topaquinone is derived by post-translational modification of a conserved tyrosine residue in the protein chain | Lathyrus sativus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.4.3.21 | seedling | - |
Lens culinaris | - |
| 1.4.3.21 | seedling | - |
Pisum sativum | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.4.3.21 | 1,4-diamino-2-butyne + H2O + O2 | - |
Onobrychis viciifolia | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-butyne + H2O + O2 | - |
Pisum sativum | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-butyne + H2O + O2 | - |
Lathyrus sativus | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-butyne + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene + H2O + O2 | - |
Onobrychis viciifolia | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene + H2O + O2 | - |
Pisum sativum | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene + H2O + O2 | - |
Lathyrus sativus | ? | - |
? | |
| 1.4.3.21 | 1,4-diamino-2-chloro-2-butene + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | 1,5-diamino-2-pentyne + H2O + O2 | - |
Onobrychis viciifolia | ? | - |
? | |
| 1.4.3.21 | 1,5-diamino-2-pentyne + H2O + O2 | - |
Pisum sativum | ? | - |
? | |
| 1.4.3.21 | 1,5-diamino-2-pentyne + H2O + O2 | - |
Lathyrus sativus | ? | - |
? | |
| 1.4.3.21 | 1,5-diamino-2-pentyne + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne + H2O + O2 | - |
Onobrychis viciifolia | ? | - |
? | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne + H2O + O2 | - |
Pisum sativum | ? | - |
? | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne + H2O + O2 | - |
Lathyrus sativus | ? | - |
? | |
| 1.4.3.21 | 1,6-diamino-2,4-hexadiyne + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | 2-bromoethylamine + H2O + O2 | - |
Onobrychis viciifolia | bromoacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | 2-bromoethylamine + H2O + O2 | - |
Pisum sativum | bromoacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | 2-bromoethylamine + H2O + O2 | - |
Lathyrus sativus | bromoacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | 2-bromoethylamine + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | bromoacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2 | - |
Onobrychis viciifolia | ? | - |
? | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2 | - |
Pisum sativum | ? | - |
? | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2 | - |
Lathyrus sativus | ? | - |
? | |
| 1.4.3.21 | 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | additional information | alkylamines 2-bromoethylamine and 2-chloroethylamine, and the short diamine 1,2-diaminoethane are both poor substrates and irreversible inactivators of LSAO | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine + H2O + O2 | - |
Onobrychis viciifolia | ? | - |
? | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine + H2O + O2 | - |
Pisum sativum | ? | - |
? | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine + H2O + O2 | - |
Lathyrus sativus | ? | - |
? | |
| 1.4.3.21 | N6-(4-aminobut-2-ynyl)adenine + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
| 1.4.3.21 | tryptamine + H2O + O2 | - |
Onobrychis viciifolia | 1H-indol-3-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tryptamine + H2O + O2 | - |
Pisum sativum | 1H-indol-3-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tryptamine + H2O + O2 | - |
Lathyrus sativus | 1H-indol-3-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tryptamine + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | 1H-indol-3-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tyramine + H2O + O2 | - |
Onobrychis viciifolia | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tyramine + H2O + O2 | - |
Pisum sativum | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tyramine + H2O + O2 | - |
Lathyrus sativus | 4-hydroxyphenylethanal + NH3 + H2O2 | - |
? | |
| 1.4.3.21 | tyramine + H2O + O2 | during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation | Lens culinaris | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.4.3.21 | dimer | - |
Onobrychis viciifolia |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.4.3.21 | Cu/TPQ amine oxidase | - |
Lens culinaris |
| 1.4.3.21 | Cu/TPQ amine oxidase | - |
Onobrychis viciifolia |
| 1.4.3.21 | Cu/TPQ amine oxidase | - |
Pisum sativum |
| 1.4.3.21 | Cu/TPQ amine oxidase | - |
Lathyrus sativus |
| 1.4.3.21 | GPAO | - |
Lathyrus sativus |
| 1.4.3.21 | grass pea amine oxidase | - |
Lathyrus sativus |
| 1.4.3.21 | lentil seedling amine oxidase | - |
Lens culinaris |
| 1.4.3.21 | LSAO | - |
Lens culinaris |
| 1.4.3.21 | OVAO | - |
Onobrychis viciifolia |
| 1.4.3.21 | pea seedling amine oxidase | - |
Pisum sativum |
| 1.4.3.21 | PSAO | - |
Pisum sativum |
| 1.4.3.21 | sainfoin amine oxidase | - |
Onobrychis viciifolia |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.21 | 2.7 | - |
tryptamine | - |
Lens culinaris | |
| 1.4.3.21 | 12.8 | - |
tyramine | - |
Lens culinaris | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.4.3.21 | topaquinone | quinone of 2,4,5-trihydroxyphenylalanine, TPQ | Lens culinaris | |
| 1.4.3.21 | topaquinone | quinone of 2,4,5-trihydroxyphenylalanine, TPQ | Onobrychis viciifolia | |
| 1.4.3.21 | topaquinone | quinone of 2,4,5-trihydroxyphenylalanine, TPQ | Pisum sativum | |
| 1.4.3.21 | topaquinone | quinone of 2,4,5-trihydroxyphenylalanine, TPQ | Lathyrus sativus | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.4.3.21 | 0.01 | - |
1,5-diamino-2-pentyne | - |
Onobrychis viciifolia | |
| 1.4.3.21 | 0.05 | - |
1,5-diamino-2-pentyne | - |
Lathyrus sativus | |
| 1.4.3.21 | 0.054 | - |
2-Bromoethylamine | - |
Lens culinaris | |
| 1.4.3.21 | 0.28 | - |
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene | - |
Lens culinaris | |
| 1.4.3.21 | 0.32 | - |
1,4-diamino-2-butyne | - |
Pisum sativum | |
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