EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.24 | cGMP | BVR localizes into the nucleus upon activation by cGMP | Rattus norvegicus | |
1.3.1.24 | cytokine | induces BVR transcription | Rattus norvegicus | |
1.3.1.24 | Ferredoxin | - |
Arabidopsis sp. | |
1.3.1.24 | heme | upregulates BVR expression | Homo sapiens | |
1.3.1.24 | hyperthermia | induces BVR transcription | Rattus norvegicus | |
1.3.1.24 | oxidant | activates | Homo sapiens | |
1.3.1.24 | oxidant | activates | Rattus norvegicus |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.3.1.24 | additional information | BVR regualtes cellular levels of biliverdin, a potent gene regulator and determinant factor for dorsal axis development in Xenopus larva | Xenopus sp. |
1.3.1.24 | additional information | interacts with the insulin receptor kinase domain, key factor in the MAPK pathway and the PI3K pathway as well as regulating PKC isoforms that link the two pathways, plays a role in the mechanism of insulin resistance | Homo sapiens |
1.3.1.24 | additional information | regulates oxidative response and HO-1 expression | Rattus norvegicus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.3.1.24 | BVR-NADH complex, NH2-terminal domain in dinucleotide binding | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.3.1.24 | additional information | changing C73 to alanine inactivates the enzyme, as it is involved in substrate/cofactor binding | Rattus norvegicus |
1.3.1.24 | additional information | point mutation of residues that in BVR interact with the adenine nucleotide, all inactivate the enzyme, S149 essential for acitvity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.24 | GATA1 | transcription factor GATA1 downregulates BVR expression | Homo sapiens | |
1.3.1.24 | SH-reactive agent | 34000 Da form extremely sensitive to, larger 68000 Da form lacks sensitivity to | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.24 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
1.3.1.24 | nucleus | - |
Rattus norvegicus | 5634 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.24 | Zn2+ | - |
Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.3.1.24 | 34000 | - |
converted to a larger 68000 Da form when rats are treated with SH-reactive agents | Rattus norvegicus |
1.3.1.24 | 68000 | - |
- |
Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.24 | Arabidopsis sp. | - |
- |
- |
1.3.1.24 | Canis lupus familiaris | - |
- |
- |
1.3.1.24 | Cavia porcellus | - |
- |
- |
1.3.1.24 | Cyanidium caldarium | - |
- |
- |
1.3.1.24 | Gallus gallus | - |
- |
- |
1.3.1.24 | Homo sapiens | - |
- |
- |
1.3.1.24 | Mus musculus | - |
- |
- |
1.3.1.24 | Pan troglodytes | - |
- |
- |
1.3.1.24 | Rattus norvegicus | - |
- |
- |
1.3.1.24 | Sus scrofa | - |
- |
- |
1.3.1.24 | Takifugu rubripes | - |
- |
- |
1.3.1.24 | Xenopus sp. | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.24 | brain | abundantly expressed | Rattus norvegicus | - |
1.3.1.24 | kidney | abundantly expressed | Rattus norvegicus | - |
1.3.1.24 | larva | - |
Xenopus sp. | - |
1.3.1.24 | liver | - |
Cavia porcellus | - |
1.3.1.24 | liver | abundantly expressed | Rattus norvegicus | - |
1.3.1.24 | renal cell carcinoma cell | increased activity of BVR, but only in the presence of NADH | Homo sapiens | - |
1.3.1.24 | spleen | abundantly expressed | Rattus norvegicus | - |
1.3.1.24 | testis | sparingly expressed | Rattus norvegicus | - |
1.3.1.24 | thymus | sparingly expressed | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.24 | biliverdin + NAD(P)H | - |
Xenopus sp. | bilirubin + NAD(P)+ | - |
? | |
1.3.1.24 | biliverdin + NAD(P)H + H+ | - |
Cavia porcellus | bilirubin + NAD(P)+ | - |
? | |
1.3.1.24 | biliverdin + NAD(P)H + H+ | - |
Arabidopsis sp. | bilirubin + NAD(P)+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.24 | BVR | - |
Gallus gallus |
1.3.1.24 | BVR | - |
Cavia porcellus |
1.3.1.24 | BVR | - |
Cyanidium caldarium |
1.3.1.24 | BVR | - |
Mus musculus |
1.3.1.24 | BVR | - |
Homo sapiens |
1.3.1.24 | BVR | - |
Rattus norvegicus |
1.3.1.24 | BVR | - |
Sus scrofa |
1.3.1.24 | BVR | - |
Canis lupus familiaris |
1.3.1.24 | BVR | - |
Arabidopsis sp. |
1.3.1.24 | BVR | - |
Xenopus sp. |
1.3.1.24 | BVR | - |
Pan troglodytes |
1.3.1.24 | BVR | - |
Takifugu rubripes |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.24 | NADH | - |
Homo sapiens | |
1.3.1.24 | NADH | used at acidic pH | Rattus norvegicus | |
1.3.1.24 | NADPH | used in the basic range | Rattus norvegicus |