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Literature summary extracted from

  • Ramirez-Montagut, T.; Blachere, N.E.; Sviderskaya, E.V.; Bennett, D.C.; Rettig, W.J.; Garin-Chesa, P.; Houghton, A.N.
    FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor (2004), Oncogene, 23, 5435-5446.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.B28 medicine tumor suppressor that abrogates tumorigenicity through regulation of cell growth and survival, in vitro, FAP expression restores contact inhibition, leads to cell cylcle arrest at G0/G1 phase, increases susceptibility to stress-induced apoptosis, and leads to caspase activation Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B28 subcloned into tetracyline-inducible vectors Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.B28 S624A FAP serine mutant lacking enzymatic activity, as wild type does not rescue dipeptidyl peptidase IV cell surface expression but is a more potent tumor suppressor than the wild type Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Mus musculus
-
 C57BL/6
-
3.4.21.B28 Mus musculus C57BL/6
-
 C57BL/6
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 embryo
-
 Mus musculus
-
3.4.21.B28 fibroblast
-
 Mus musculus
-
3.4.21.B28 melanocyte
-
 Mus musculus
-
3.4.21.B28 additional information not expressed in melanomas Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 FAP
-
 Mus musculus
3.4.21.B28 FAPalpha
-
 Mus musculus