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Literature summary extracted from

  • Takemoto-Kimura, S.; Ageta-Ishihara, N.; Nonaka, M.; Adachi-Morishima, A.; Mano, T.; Okamura, M.; Fujii, H.; Fuse, T.; Hoshino, M.; Suzuki, S.; Kojima, M.; Mishina, M.; Okuno, H.; Bito, H.
    Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma (2007), Neuron, 54, 755-770.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.17 Calmodulin dependent on Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expression of wild-type and mutant CL3 in COS-7 cells, expression of HA- or GFP-tagged wild-type CL3 in cortical neurons Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.17 C417S/C419S/C420S/C423S site-directed mutagenesis, mutation of palmitoylation sites Mus musculus
2.7.11.17 K52A site-directed mutagenesis, inactive mutant, loss-of-function in embryonic cortical neurons elicits a specific impairment in dendrite morphogenesis Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 dendrite dendritic raft targeting Mus musculus 30425
-
2.7.11.17 Golgi membrane anchored, perinuclear Golgi-like membranes Mus musculus 139
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 additional information Mus musculus the enzyme is involved in dendritogenesis in cortical neurons and is required for brain-derived neurotropic factor-stimulated dendritic growth, and regulation of dendritic morphogenesis via the lipid-raft-delineated CL3-STEF-RAc pathway contributing to the development of cortical dendrites, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 lipoprotein the enzyme is modified in two sequential lipidification steps, CAAX prenylation followed by kinase-activity-regulated palmitoylation at C417, C419, C420, and C423, the modifications are essential for CL3 membrane anchoring and targeting of the enzyme into detergent-resistant lipid microdomains or rafts in dendrites, overview Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.17 brain
-
 Mus musculus
-
2.7.11.17 neuron cortical, expression in developing cortex, dendritic localization Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 additional information the enzyme is involved in dendritogenesis in cortical neurons and is required for brain-derived neurotropic factor-stimulated dendritic growth, and regulation of dendritic morphogenesis via the lipid-raft-delineated CL3-STEF-RAc pathway contributing to the development of cortical dendrites, overview Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.17 More multimeric complex formation by CL3 in cortical neurons Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 CL3
-
 Mus musculus
2.7.11.17 CLICK-III/CaMKIgamma
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.17 ATP
-
 Mus musculus