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Literature summary extracted from

  • Sanchez, P.; Torres, J.M.; Ortega, E.
    Effects of dihydrotestosterone on brain mRNA levels of steroid 5alpha-reductase isozymes in early postnatal life of rat (2005), Neurochem. Res., 30, 577-581.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.22 dihydrotestosterone significantly increases 5alpha-R1 mRNA and 5alpha-R2 mRNA expression in male rats Rattus norvegicus

Application

EC Number Application Comment Organism
1.3.1.22 medicine higher expression of 5alpha-R2, which is considered a masculinizing enzyme, in the female versus male central nervous system, sexual dimorphism in the regulation of 5alpha isozymes by dihydrotestosterone Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 dihydrotestosterone significantly decreases 5alpha-R1 mRNA and 5alpha-R2 mRNA expression in female rats Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 brain
-
 Rattus norvegicus
-
1.3.1.22 central nervous system
-
 Rattus norvegicus
-
1.3.1.22 prefrontal cortex similar 5alpha-R1 mRNA expression in female and male rats, 5alpha-R2 mRNA expression significantly higher in females than in males Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 5alpha-R1
-
 Rattus norvegicus
1.3.1.22 5alpha-R2
-
 Rattus norvegicus
1.3.1.22 steroid 5alpha-reductase
-
 Rattus norvegicus
1.3.1.22 type 1 steroid 5alpha-reductase
-
 Rattus norvegicus
1.3.1.22 type 2 steroid 5alpha-reductase
-
 Rattus norvegicus