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Literature summary extracted from

  • Balestri, F.; Barsotti, C.; Lutzemberger, L.; Camici, M.; Ipata, P.L.
    Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain (2007), Neurochem. Int., 51, 517-523.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.3 additional information Homo sapiens catalyzes the first step of uridine degradation to beta-alanine in liver ?
-
 ?
2.4.2.3 additional information Rattus norvegicus catalyzes the first step of uridine degradation to beta-alanine in liver ?
-
 ?
2.7.1.48 additional information Rattus norvegicus uridine kinase and uridine phosphorylase are involved in the homeostatic regulation of purine and pyrimidine metabolism in brain. At relatively low UTP and CTP level, uptaken uridine is mainly anabolized to uridine nucleotides. At relatively high UTP and CTP levels, the inhibition of uridine kinase channels uridine towards phosphorolysis, resulting in 5-phosphoribosyl-1-bisphosphate used for purine salvage synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-
2.4.2.3 Rattus norvegicus
-
-
-
2.7.1.48 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 astrocytoma cell
-
 Homo sapiens
-
2.4.2.3 brain
-
 Rattus norvegicus
-
2.7.1.48 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 additional information catalyzes the first step of uridine degradation to beta-alanine in liver Homo sapiens ?
-
 ?
2.4.2.3 additional information catalyzes the first step of uridine degradation to beta-alanine in liver Rattus norvegicus ?
-
 ?
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Rattus norvegicus uracil + alpha-D-ribose 1-phosphate
-
 ?
2.7.1.48 ATP + uridine
-
 Rattus norvegicus ADP + UMP
-
 ?
2.7.1.48 additional information uridine kinase and uridine phosphorylase are involved in the homeostatic regulation of purine and pyrimidine metabolism in brain. At relatively low UTP and CTP level, uptaken uridine is mainly anabolized to uridine nucleotides. At relatively high UTP and CTP levels, the inhibition of uridine kinase channels uridine towards phosphorolysis, resulting in 5-phosphoribosyl-1-bisphosphate used for purine salvage synthesis Rattus norvegicus ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.48 ATP
-
 Rattus norvegicus