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Literature summary extracted from

  • Fuchs, R.T.; Grundy, F.J.; Henkin, T.M.
    The S(MK) box is a new SAM-binding RNA for translational regulation of SAM synthetase (2006), Nat. Struct. Mol. Biol., 13, 226-233.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.6 gene metK, expression in Bacillus subtilis Enterococcus faecalis

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.6 additional information mutational analysis and structural mapping of the the S(MK) box, conserved RNA motif in the 5'-untranslated region of the metK gene, overview Enterococcus faecalis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.6 K+
-
 Enterococcus faecalis
2.5.1.6 Mg2+
-
 Enterococcus faecalis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O Enterococcus faecalis the S(MK) box, a conserved RNA motif in the 5'-untranslated region of the metK gene, is a SAM-binding RNA responsible for translational regulation of the enzyme, it binds specifically to S-adenosyl-L-methionine in vitro and in vivo causing a structural RNA rearrangement that causes a sequestration of the Shine-Dalgarno sequence, structural mapping and mechanism, overview phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.6 Enterococcus faecalis
-
 gene metK
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.6 ATP + L-methionine + H2O the S(MK) box, a conserved RNA motif in the 5'-untranslated region of the metK gene, is a SAM-binding RNA responsible for translational regulation of the enzyme, it binds specifically to S-adenosyl-L-methionine in vitro and in vivo causing a structural RNA rearrangement that causes a sequestration of the Shine-Dalgarno sequence, structural mapping and mechanism, overview Enterococcus faecalis phosphate + diphosphate + S-adenosyl-L-methionine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.6 More structural mapping of the the S(MK) box, conserved RNA motif in the 5'-untranslated region of the metK gene, overview Enterococcus faecalis

Synonyms

EC Number Synonyms Comment Organism
2.5.1.6 SAM synthetase
-
 Enterococcus faecalis

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.6 ATP
-
 Enterococcus faecalis