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Literature summary extracted from

  • Nawaratne, R.; Gray, A.; Jorgensen, C.H.; Downes, C.P.; Siddle, K.; Sethi, J.K.
    Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation (2006), Mol. Endocrinol., 20, 1838-1852.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.13 diacylglycerol
-
 Rattus norvegicus
2.7.11.13 additional information no activation by C2 ceramide or chronic insulin treatment Rattus norvegicus
2.7.11.13 phorbol 12-myristate 13-acetate stimulates IRS1 Ser24 phosphorylation in vivo Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.13 Gö6976 an inhibitor of isozymes cPKCalpha, -beta, and -my Rattus norvegicus
2.7.11.13 Gö6983 an inhibitor of isozyme PKCbeta, but not of PKCmy Rattus norvegicus
2.7.11.13 rottlerin a selective inhibitor of nPKCdelta and PKCtheta Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.13 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.13 ATP + insulin receptor substrate 1 Rattus norvegicus phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview ADP + phosphorylated insulin receptor substrate 1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.13 Rattus norvegicus
-
 several PKC isozymes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.13 cell culture NIH/hIR/rIRS1cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.13 ATP + insulin receptor substrate 1 phosphorylation of insulin receptor substrate proteins on serine residues is an important posttranslational modification that is linked to insulin resistance, overview Rattus norvegicus ADP + phosphorylated insulin receptor substrate 1
-
 ?
2.7.11.13 ATP + insulin receptor substrate 1 a bona fide substrate for conventional isozymes PKCalpha, PKCzeta, and PKCdelta, phosphorylation of IRS1 at Ser24 in the N-terminal pleckstrin homology domain of IRS1, additionally isozyme PKCalpha is indirectly involved in Ser307 and Ser612 phosphorylation Rattus norvegicus ADP + phosphorylated insulin receptor substrate 1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.13 PKC
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.13 ATP
-
 Rattus norvegicus