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Literature summary extracted from

  • Hubacek, J.A.; Bobkova, D.
    Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering (2006), Mol. Diagn. Ther., 10, 93-100.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.23 additional information enzyme expression is induced by cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.23 gene CYP7A1, genetic structure, the gene contains six exons and five introns and is located on chromosome 8 at 8q11-q12, CYP7A1 mRNA levels are regulated through the farnesoid X receptor and the liver X receptor by many stimuli including cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.23 A204C nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene, the genetic variant shows less total cholesterol level decrease in response to dietary changes in different types of dietary intervention studies compared to C204 homozygotes, overview Homo sapiens
1.14.14.23 A278C nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene Homo sapiens
1.14.14.23 C554T nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene Homo sapiens
1.14.14.23 additional information genotyping and frequency of polymorphisms in human populations, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.23 Homo sapiens P22680 gene CYP7A1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.23 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.23 cholesterol 7alpha-hydroxylase
-
 Homo sapiens
1.14.14.23 CYP7A1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.23 NADPH
-
 Homo sapiens