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Literature summary extracted from

  • Hu, C.A.; Donald, S.P.; Yu, J.; Lin, W.W.; Liu, Z.; Steel, G.; Obie, C.; Valle, D.; Phang, J.M.
    Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis (2007), Mol. Cell. Biochem., 295, 85-92.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.99.B2 L-proline in the presence of L-proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.99.B2 expressed in DLD-1.POX cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.99.B2 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.5.99.B2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.99.B2 colorectal cancer cell
-
 Homo sapiens
-
1.5.99.B2 DLD-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.99.B2 L-proline + cytochrome c + H2O
-
 Homo sapiens (S)-1-pyrroline-5-carboxylate + reduced cytochrome c
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.99.B2 POX
-
 Homo sapiens
1.5.99.B2 PRODH
-
 Homo sapiens
1.5.99.B2 proline dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.99.B2 FAD
-
 Homo sapiens