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Literature summary extracted from

  • Fragopoulou, E.; Iatrou, C.; Demopoulos, C.A.
    Characterization of acetyl-CoA:lyso-PAF acetyltransferase of human mesangial cells (2005), Mediators Inflamm., 2005, 263-272.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.67 NaF slightly increases activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 2-mercaptoethanol
-
 Homo sapiens
2.3.1.67 CaCl2 10 mM, 46% inhibition Homo sapiens
2.3.1.67 dithiothreitol
-
 Homo sapiens
2.3.1.67 EDTA 1 mM, 47% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.67 0.00921
-
 lyso-platelet-activating factor total membrane fractions of mesangial cells Homo sapiens
2.3.1.67 0.0712
-
 acetyl-CoA total membrane fractions of mesangial cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.67 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 kidney
-
 Homo sapiens
-
2.3.1.67 mesangial cell the enzyme is activated under inflammatory conditions Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor
-
 Homo sapiens platelet-activating factor + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.67 acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase
-
 Homo sapiens
2.3.1.67 lyso-PAF acetyltransferase
-
 Homo sapiens
2.3.1.67 lyso-PAF AT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.67 7.2 7.4
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.1.67 6 9 pH 6.0: about 80% of maximal activity, pH 9.0: about 70% of maximal activity Homo sapiens