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Literature summary extracted from

  • Chen, W.; Suruga, K.; Nishimura, N.; Gouda, T.; Lam, V.N.; Yokogoshi, H.
    Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats (2005), Life Sci., 77, 746-757.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.139 additional information feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 Rattus norvegicus
1.14.14.139 additional information feeding of taurine alone has no effect on enzyme expression Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.139 additional information feeding of cholic acid suppresses expression of CYP8B1, the effect is partly reversed by taurine, feeding of taurine alone has no effect on enzyme expression Mus musculus
1.14.14.139 additional information feeding of cholic acid, taurine, or cholesterol does not affect expression of CYP8B1 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.139 microsome
-
 Mus musculus
-
-
1.14.14.139 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Mus musculus
-
 10-weeks-old male C75BL/6 mice
-
1.14.14.139 Rattus norvegicus
-
 5-weeks-old male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 liver
-
 Mus musculus
-
1.14.14.139 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 CYP8B1
-
 Mus musculus
1.14.14.139 CYP8B1
-
 Rattus norvegicus
1.14.14.139 sterol 12alpha-hydroxylase
-
 Mus musculus
1.14.14.139 sterol 12alpha-hydroxylase
-
 Rattus norvegicus