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Literature summary extracted from

  • Shimizu, S.; Yoshida, T.; Wakamori, M.; Ishii, M.; Okada, T.; Takahashi, M.; Seto, M.; Sakurada, K.; Kiuchi, Y.; Mori, Y.
    Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells (2006), J. Physiol., 570, 219-235.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 Calmodulin activates, dependent on Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.18 DNA and amino acid sequence determination and analysis, expressionin HEK-293 cells, co-expression with TRPC5 from Drosophila melanogaster Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.18 additional information expression of a dominant-negative mutant of MLCK inhibits the TRPC5 channel activity, revealing an essential role of MLCK in maintaining TRPC5 channel activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 ML-9 impairs the plasma membrane localization of TRPC5 channels; impairs the plasma membrane localization of TRPC5 channels Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+ activates, dependent on Homo sapiens
2.7.11.18 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens Q15746 smooth muscle isozyme MYLK
-
2.7.11.18 Homo sapiens Q9H1R3 skeletal/cardiac muscle isozyme MYLK2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 cardiac muscle
-
 Homo sapiens
-
2.7.11.18 skeletal muscle
-
 Homo sapiens
-
2.7.11.18 smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + TRPC5 channel Ca2+/calmodulin-dependent myosin light chain kinase is essential for activation of plasma membrane TRPC5 channels, responsible for Ca2+ influx, from Drosophila melanogaster expressed in HEK-293 cells, phosphorylation sites are Ser698, Ser775, and Thr700, mutational analysis Homo sapiens ADP + phosphorylated TRPC5 channel
-
 ?
2.7.11.18 additional information MLCK in the plasma membrane distribution of TRPC5 channels, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 Ca2+-calmodulin-dependent myosin light chain kinase
-
 Homo sapiens
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 More cf. EC 2.7.11.17 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Homo sapiens