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Literature summary extracted from

  • Velu, S.E.; Mou, L.; Luan, C.H.; Yang, Z.W.; DeLucas, L.J.; Brouillette, C.G.; Brouillette, W.J.
    Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups (2007), J. Med. Chem., 50, 2612-2621.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.1.5
-
 Bacillus subtilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.5 1-(4-benzyloxyphenoxy)-8-(2-guanidino-2-phenyl-1-ethyloxy)-octane
-
 Bacillus subtilis
6.3.1.5 1-(4-benzyloxyphenoxy)-8-(2-guanidino-3-phenyl-1-propyloxy)-octane
-
 Bacillus subtilis
6.3.1.5 1-(4-benzyloxyphenoxy)-8-(2-N,N,N-trimethylammonium-2-phenyl-1-ethyloxy)octane
-
 Bacillus subtilis
6.3.1.5 1-(4-benzyloxyphenoxy)-8-(2-N,N,N-trimethylammonium-3-phenyl-1-propyloxy)octane
-
 Bacillus subtilis
6.3.1.5 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-(1H-indol-3-yl)propionate
-
 Bacillus subtilis
6.3.1.5 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-(4-hydroxyphenyl)propionate
-
 Bacillus subtilis
6.3.1.5 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-phenylpropionate
-
 Bacillus subtilis
6.3.1.5 ampicillin
-
 Bacillus subtilis
6.3.1.5 Ciprofloxacin
-
 Bacillus subtilis
6.3.1.5 clotrimazole
-
 Bacillus subtilis
6.3.1.5 doxycycline
-
 Bacillus subtilis
6.3.1.5 Methicillin
-
 Bacillus subtilis
6.3.1.5 additional information clotrimazole does not inhibit in the presence of 0.01% Triton X-100 Bacillus subtilis
6.3.1.5 N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-(N,N,N-trimethylammonium)-2-phenylacetamide
-
 Bacillus subtilis
6.3.1.5 N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-(N,N,N-trimethylammonium)-3-phenylpropionamide
-
 Bacillus subtilis
6.3.1.5 N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-guanidino-2-phenylacetamide
-
 Bacillus subtilis
6.3.1.5 N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-guanidino-3-phenylpropionamide
-
 Bacillus subtilis
6.3.1.5 Rifampin
-
 Bacillus subtilis

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
6.3.1.5 Triton X-100 inhibitory effects toward the enzyme are decreased in the presence of Triton X-100 Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.5 Bacillus subtilis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.1.5
-
 Bacillus subtilis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.1.5 ATP + deamido-NAD+ + NH3
-
 Bacillus subtilis AMP + diphosphate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.1.5 NAD synthetase
-
 Bacillus subtilis

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.1.5 ATP
-
 Bacillus subtilis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.1.5 0.011
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 1-(4-benzyloxyphenoxy)-8-(2-guanidino-3-phenyl-1-propyloxy)-octane
6.3.1.5 0.011
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 1-(4-benzyloxyphenoxy)-8-(2-guanidino-2-phenyl-1-ethyloxy)-octane
6.3.1.5 0.012
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-guanidino-3-phenylpropionamide
6.3.1.5 0.019
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-(1H-indol-3-yl)propionate
6.3.1.5 0.019
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-guanidino-2-phenylacetamide
6.3.1.5 0.021
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 1-(4-benzyloxyphenoxy)-8-(2-N,N,N-trimethylammonium-3-phenyl-1-propyloxy)octane
6.3.1.5 0.037
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5, in the presence of 0.01% Triton X-100 Bacillus subtilis 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-phenylpropionate
6.3.1.5 0.038
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 1-(4-benzyloxyphenoxy)-8-(2-N,N,N-trimethylammonium-2-phenyl-1-ethyloxy)octane
6.3.1.5 0.04
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-(N,N,N-trimethylammonium)-3-phenylpropionamide
6.3.1.5 0.045
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis N-[8-(4-benzyloxyphenoxy)-1-octyl]-2-(N,N,N-trimethylammonium)-2-phenylacetamide
6.3.1.5 0.053
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-(4-hydroxyphenyl)propionate
6.3.1.5 0.22
-
 in 58.5 mM HEPPS buffer, 18.5 mM NH4Cl, 19.5 mM KCl, 9.75 mM MgCl2, 1% (v/v) EtOH, at pH 8.5 Bacillus subtilis 8-(4-benzyloxyphenoxy)-1-octyl 2-(N,N,N-trimethylammonium)-3-phenylpropionate