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Literature summary extracted from

  • Mai, A.; Rotili, D.; Tarantino, D.; Ornaghi, P.; Tosi, F.; Vicidomini, C.; Sbardella, G.; Nebbioso, A.; Miceli, M.; Altucci, L.; Filetici, P.
    Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties (2006), J. Med. Chem., 49, 6897-6907.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 3-quinolinecarboxylic acid ethyl ester effects in vivo, overview Homo sapiens
2.3.1.48 3-quinolinecarboxylic acid ethyl ester effects in vivo, inhibitory effect on the transcription is not fully GCN5-specific, overview Saccharomyces cerevisiae
2.3.1.48 4-hydroxy-2-pentylquinoline-3-carboxylate effects in vivo, overview, in vitro clear reduction of the acetylation extents of both histone H3 and alpha-tubulin at 0.1 mM Homo sapiens
2.3.1.48 4-hydroxy-2-pentylquinoline-3-carboxylic acid
-
 Saccharomyces cerevisiae
2.3.1.48 anacardic acid
-
 Homo sapiens
2.3.1.48 anacardic acid
-
 Saccharomyces cerevisiae
2.3.1.48 curcumin
-
 Homo sapiens
2.3.1.48 curcumin
-
 Saccharomyces cerevisiae
2.3.1.48 ethyl 2-methylquinoline-3-carboxylate effects in vivo, overview Homo sapiens
2.3.1.48 ethyl 2-methylquinoline-3-carboxylate effects in vivo, inhibitory effect on the transcription is fully GCN5-specific, overview Saccharomyces cerevisiae
2.3.1.48 garcinol
-
 Homo sapiens
2.3.1.48 garcinol
-
 Saccharomyces cerevisiae
2.3.1.48 H3-CoA-20
-
 Homo sapiens
2.3.1.48 H3-CoA-20
-
 Saccharomyces cerevisiae
2.3.1.48 isothiazolone
-
 Homo sapiens
2.3.1.48 isothiazolone
-
 Saccharomyces cerevisiae
2.3.1.48 Lys-CoA
-
 Homo sapiens
2.3.1.48 Lys-CoA
-
 Saccharomyces cerevisiae
2.3.1.48 MB-3
-
 Homo sapiens
2.3.1.48 MB-3
-
 Saccharomyces cerevisiae
2.3.1.48 additional information screening for small molecule inhibitors reducing the cell growth, overview Homo sapiens
2.3.1.48 additional information screening for small molecule inhibitors reducing the cell growth, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 histone H3 + acetyl-CoA Homo sapiens
-
 acetyl-histone H3 + CoA
-
 ?
2.3.1.48 histone H3 + acetyl-CoA Saccharomyces cerevisiae
-
 acetyl-histone H3 + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens
-
-
-
2.3.1.48 Saccharomyces cerevisiae
-
 several strains
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 U-937 cell leukemia cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 alpha-tubulin + acetyl-CoA
-
 Homo sapiens acetyl-alpha-tubulin + CoA
-
 ?
2.3.1.48 alpha-tubulin + acetyl-CoA
-
 Saccharomyces cerevisiae acetyl-alpha-tubulin + CoA
-
 ?
2.3.1.48 histone H3 + acetyl-CoA
-
 Homo sapiens acetyl-histone H3 + CoA
-
 ?
2.3.1.48 histone H3 + acetyl-CoA
-
 Saccharomyces cerevisiae acetyl-histone H3 + CoA
-
 ?
2.3.1.48 histone H3 tail peptide + acetyl-CoA
-
 Saccharomyces cerevisiae acetyl-histone H3 tail peptide + CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.48 acetyl-CoA
-
 Homo sapiens
2.3.1.48 acetyl-CoA
-
 Saccharomyces cerevisiae