EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.12 | 1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] | more than 90% inhibition at 0.1 mM | Trypanosoma cruzi | |
1.8.1.12 | 1-(1H-indol-5-yl)-N-[(4-methylpiperazin-1-yl)methyl]methanediamine | 0.1 mM, 31% or 39% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide, respectively | Trypanosoma cruzi | |
1.8.1.12 | 1-(3-bromothiophen-2-yl)-N-(pyridin-3-ylmethyl)methanediamine | 0.1 mM, 15% or 14% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide, respectively | Trypanosoma cruzi | |
1.8.1.12 | N-(pyridin-3-ylmethyl)-1-thiophen-2-ylmethanediamine | 0.1 mM, 10% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide | Trypanosoma cruzi | |
1.8.1.12 | N-[(4-methylpiperazin-1-yl)methyl]-1-thiophen-2-ylmethanediamine | 0.1 mM, 10% inhibition in the presence of 0.11 mM or 0.04 mM trypanothione disulfide | Trypanosoma cruzi | |
1.8.1.12 | N-[2-[(naphthalen-1-ylacetyl)amino]ethyl]-4-[[(3-nitrophenyl)(oxo)acetyl]amino]piperidine-4-carboxamide | 0.1 mM | Trypanosoma cruzi |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.12 | Trypanosoma cruzi | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.12 | trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.12 | TR | - |
Trypanosoma cruzi |
1.8.1.12 | trypanothione reductase | - |
Trypanosoma cruzi |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.12 | NADPH | - |
Trypanosoma cruzi |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.12 | 0.002 | - |
1,1'-hexamethylenebis[5-(4-chlorophenyl)biguanide] | - |
Trypanosoma cruzi | |
1.8.1.12 | 0.009 | - |
N-[2-[(naphthalen-1-ylacetyl)amino]ethyl]-4-[[(3-nitrophenyl)(oxo)acetyl]amino]piperidine-4-carboxamide | mixed type inhibitor, 0.1 mM | Trypanosoma cruzi |