Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sehayek, E.; Hagey, L.R.; Fung, Y.Y.; Duncan, E.M.; Yu, H.J.; Eggertsen, G.; Bjoerkhem, I.; Hofmann, A.F.; Breslow, J.L.
    Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit (2006), J. Lipid Res., 47, 2020-2027.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.139 gene CYP8B1, genotyping of different strains of mice, e.g. C57BL/6J and CASA/Rk mice, and a hybrid of both Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.139 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Mus musculus
-
 C57BL/6J and CASA/Rk mice, and a hybrid of both
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.139 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 the enzyme channels bile acid precursors into cholic acid, but is not affected on mRNA and protein levels by increased cholic acid or reduced beta-muricholic acid levels, overview Mus musculus 12-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 CYP8B1
-
 Mus musculus
1.14.14.139 sterol 12alpha-hydroxylase
-
 Mus musculus