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Literature summary extracted from

  • Lu, B.; Jiang, Y.J.; Man, M.Q.; Brown, B.; Elias, P.M.; Feingold, K.R.
    Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis (2005), J. Lipid Res., 46, 2448-2457.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.51 additional information isozyme AGPAT2 and AGPAT5 expression increase in parallel with both an increase in enzyme activity and permeability barrier formation late in rat epidermal development, acute permeability barrier disruption, by tape-stripping, leads to rapidly increased expression of isozymes AGPAT 1, 2, and 3, reversible by occlusion Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Mus musculus the expression of AGPATs is linked to skin barrier requirements CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Mus musculus
-
 isozymes AGPAT1,2,3, and 5
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.51 epidermis isozyme AGPAT2 and AGPAT5 expression increase in parallel with both an increase in enzyme activity and permeability barrier formation late in rat epidermal development, acute permeability barrier disruption leads to rapidly increased expression of isozymes AGPAT 1, 2, and 3 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate the expression of AGPATs is linked to skin barrier requirements Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.51 1-acyl-sn-glycerol-3-phosphate acyltransferase
-
 Mus musculus
2.3.1.51 AGPAT
-
 Mus musculus