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Literature summary extracted from

  • Gumustekin, K.; Ciftci, M.; Coban, A.; Altikat, S.; Aktas, O.; Gul, M.; Timur, H.; Dane, S.
    Effects of nicotine and vitamin E on glucose 6-phosphate dehydrogenase activity in some rat tissues in vivo and in vitro (2005), J. Enzyme Inhib. Med. Chem., 20, 497-502.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.49 vitamin E in concert with nicotine the enzyme from testis brain and liver is inhibited, while the enzyme from muscle and stomach is activated by 36% and 20%, respectively, overview Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 Nicotine inhibits the enzyme from lung, testis, kidney, stomach, and brain, in concert with vitamin E the enzyme from testis brain and liver is inhibited, tissue-specific inhibition of 12.5-48%, overview, nicotine has no effect on enzyme from muscle, heart, and liver Rattus norvegicus
1.1.1.49 vitamin E in concert with nicotine the enzyme from testis brain and liver is inhibited, while the enzyme from muscle and stomach is activated, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+ Rattus norvegicus
-
 D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Rattus norvegicus
-
 Sprague-Dawley rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.49 partial purification of the enzyme from different tissues by ammonium sulfate fractionation and dialysis Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 brain
-
 Rattus norvegicus
-
1.1.1.49 heart
-
 Rattus norvegicus
-
1.1.1.49 kidney
-
 Rattus norvegicus
-
1.1.1.49 liver
-
 Rattus norvegicus
-
1.1.1.49 lung
-
 Rattus norvegicus
-
1.1.1.49 muscle
-
 Rattus norvegicus
-
1.1.1.49 stomach
-
 Rattus norvegicus
-
1.1.1.49 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.49 D-glucose 6-phosphate + NADP+
-
 Rattus norvegicus D-glucono-1,5-lactone 6-phosphate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.49 G-6PD
-
 Rattus norvegicus
1.1.1.49 glucose 6-phosphate dehydrogenase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.49 25
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.49 8
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.49 NADP+
-
 Rattus norvegicus