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Literature summary extracted from

  • Xue, Y.; Zhang, Z.; Karaplis, A.C.; Hendy, G.N.; Goltzman, D.; Miao, D.
    Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice (2005), J. Bone Miner. Res., 20, 1766-1777.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.18 additional information construction of 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice, NH2-terminal fragments of PTH and PTH-related protein, PTHrP, on the skeleton of young mutant mice is an increase in both endochondral bone and appositional formation without increased bone resorption, phenotype, overview, PTH is the major protein hormone regulating calcium homeostasis, PTHrP is a PTH-like factor responsible for humoral hypercalcemia of malignancy, both peptides are required to achieve normal fetal skeletal morphogenesis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2 Mus musculus
-
 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information Mus musculus PTH and PTHrP are involved in enzyme regulation, PTH is the major protein hormone regulating calcium homeostasis, PTHrP is a PTH-like factor responsible for humoral hypercalcemia of malignancy, both peptides are required to achieve normal fetal skeletal morphogenesis, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 bone
-
 Mus musculus
-
1.14.15.18 skeletal system
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2
-
 Mus musculus 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information PTH and PTHrP are involved in enzyme regulation, PTH is the major protein hormone regulating calcium homeostasis, PTHrP is a PTH-like factor responsible for humoral hypercalcemia of malignancy, both peptides are required to achieve normal fetal skeletal morphogenesis, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.18 25-hydroxyvitamin D-1alpha-hydroxylase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.18 Ferredoxin
-
 Mus musculus
1.14.15.18 NADPH
-
 Mus musculus