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Literature summary extracted from

  • Stephens, J.L.; Lee, S.H.; Paul, K.S.; Englund, P.T.
    Mitochondrial fatty acid synthesis in Trypanosoma brucei (2007), J. Biol. Chem., 282, 4427-4436.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.41 additional information construction of FAS or ELO enzyme-deficient mutant strains by RNA interference or gene disruption, ACP depletion by RNAi or gene knockout reduces lipoic acid levels and drastically decreases protein lipoylation Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.41 microsome enzyme in the fatty acid synthase complex Trypanosoma brucei
-
-
2.3.1.41 mitochondrion enzyme in the elongase complex Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.41 additional information Trypanosoma brucei the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.41 Trypanosoma brucei Q586W9 mitochondrial beta-ketoacyl synthase; ssp. brucei, strain 427, procyclic trypanosomes
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.41 additional information
-
-
 Trypanosoma brucei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.41 additional information the organism, with the unusual lipid metabolism of the trypanosome, uses a microsomal elongase pathway, ELO, for de novo fatty acid synthesis, a second FAS pathway with a type II synthase is localized to the mitochondrion and is essential for bloodstream and procyclic life cycle stages of the parasite, in vivo precursors of mitochondrial fatty acid synthesis, overview Trypanosoma brucei ?
-
 ?
2.3.1.41 additional information octanoate, the precursor for lipoic acid synthesis, is also produced by the mitochondrial FAS Trypanosoma brucei ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.41 beta-ketoacyl-ACP synthase
-
 Trypanosoma brucei
2.3.1.41 elongase
-
 Trypanosoma brucei

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.41 37
-
 assay at Trypanosoma brucei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.41 7.5
-
 assay at Trypanosoma brucei