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Literature summary extracted from

  • Tracy, B.S.; Avci, F.Y.; Linhardt, R.J.; DeAngelis, P.L.
    Acceptor specificity of the Pasteurella hyaluronan and chondroitin synthases and production of chimeric glycosaminoglycans (2007), J. Biol. Chem., 282, 337-344.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.212 synthesis it may be possible to generate compounds that will selectively inhibit the binding of hyaluronan to one particular hyaladherin species without perturbing other species. Such sugar molecules may have future utility as selective therapeutics with minimal side effects for diseases such as cancer, autoimmune disease, inflammation, and infection Pasteurella multocida

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Pasteurella multocida
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.212 additional information PmHAS elongates a range of acceptor molecules in addition to the cognate sugars. Certain glycosaminoglycans are very poor acceptors in comparison to the cognate molecules, but elongated products are detected. The interaction between the acceptor and the enzyme (a) the orientation of the hydroxyl at the C-4 position of the hexosamine is not critical, (b) the conformation of C-5 of the hexuronic acid (glucuronic versus iduronic) is not crucial, and (c) additional negative sulfate groups are well tolerated in certain cases, such as on C-6 of the hexosamine, but others, including C-4 sulfates, are not or are poorly tolerated Pasteurella multocida ?
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2.4.1.212 UDP-D-glucuronate + chondroitin 4-sulfate trisaccharide 3.6% of the activity with hyaluronan Pasteurella multocida ?
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2.4.1.212 UDP-D-glucuronate + chondroitin 6-sulfate pentasaccharide 61% of the activity with hyaluronan Pasteurella multocida ?
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2.4.1.212 UDP-D-glucuronate + chondroitin 6-sulfate trisaccharide 80% of the activity with hyaluronan Pasteurella multocida ?
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2.4.1.212 UDP-D-glucuronate + chondroitin sulfate 12% of the activity with hyaluronan Pasteurella multocida ?
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2.4.1.212 UDP-D-glucuronate + unsulfated chondroitin 54% of the activity with hyaluronan Pasteurella multocida ?
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 PmHAS
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 Pasteurella multocida