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Literature summary extracted from

  • Letts, J.A.; Rose, N.L.; Fang, Y.R.; Barry, C.H.; Borisova, S.N.; Seto, N.O.; Palcic, M.M.; Evans, S.V.
    Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases (2006), J. Biol. Chem., 281, 3625-3632.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.37 enzyme soaked with acceptor analogs: galactose, lactose, N-acetyllactosamine, beta-D-Galp-O(CH2)8CO2CH3, alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3, beta-D-Galp-(1,4)-beta-D-Glcp-OCH3, alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-D-GlcNAcp-O(CH2)7CH3, alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 Homo sapiens
2.4.1.40 enzyme soaked with acceptor analogs: galactose, lactose, N-acetyllactosamine, beta-D-Galp-O(CH2)8CO2CH3, alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3, beta-D-Galp-(1,4)-beta-D-Glcp-OCH3, alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-D-GlcNAcp-O(CH2)7CH3, alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.37 0.022
-
alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens
2.4.1.37 0.184
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 37°C, pH 7.0 Homo sapiens
2.4.1.37 1.6
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens
2.4.1.40 0.087
-
alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens
2.4.1.40 0.49
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 37°C, pH 7.0 Homo sapiens
2.4.1.40 1.3
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.37 Homo sapiens P16442
-
-
2.4.1.40 Homo sapiens P16442
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.37 UDP-D-galactose + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3 69% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 Homo sapiens UDP + alpha-L-Fuc-(1,2)-[alpha-D-Galp-(1,3)-]-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3
-
?
2.4.1.37 UDP-D-galactose + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 90% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 Homo sapiens UDP + alpha-L-Fucp-(1,2)-[alpha-D-Galp-(1,3)-]-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3
-
?
2.4.1.37 UDP-D-galactose + alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3
-
Homo sapiens UDP + alpha-L-Fuc-(1,2)-[alpha-D-Galp-(1,3)-]-beta-D-Galp-O(CH2)7CH3
-
?
2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3 41% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 Homo sapiens ?
-
?
2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 79% of the activity with alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 Homo sapiens ?
-
?
2.4.1.40 UDP-N-acetyl-D-galactosamine + alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3
-
Homo sapiens UDP + alpha-D-GalNAc-(1,3)-[alpha-(Fucp-(1,2)])-beta-D-Galp-O(CH2)7CH3
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.37 glycosyltransferases B
-
Homo sapiens
2.4.1.37 GTB
-
Homo sapiens
2.4.1.40 glycosyltransferases A
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.1.37 0.5
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-D-GlcNAcp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens
2.4.1.37 1.2
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O(CH2)8CO2CH3 37°C, pH 7.0 Homo sapiens
2.4.1.37 3.5
-
alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens
2.4.1.40 1.3
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,3)-beta-DGlcNAcp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens
2.4.1.40 1.8
-
alpha-L-Fucp-(1,2)-beta-D-Galp-(1,4)-beta-D-GlcNAcp-O-(CH2)8CO2CH3 37°C, pH 7.0 Homo sapiens
2.4.1.40 7.6
-
alpha-L-Fucp-(1,2)-beta-D-Galp-O(CH2)7CH3 37°C, pH 7.0 Homo sapiens