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Literature summary extracted from

  • Sharpley, M.S.; Hirst, J.
    The inhibition of mitochondrial complex I (NADH:ubiquinone oxidoreductase) by Zn2+ (2006), J. Biol. Chem., 281, 34803-34809.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 Ba2+ 1 mM Bos taurus
7.1.1.2 Ca2+ 1 mM Bos taurus
7.1.1.2 Cd2+ 1 mM, potent inhibitor Bos taurus
7.1.1.2 Co2+ 1 mM Bos taurus
7.1.1.2 Cu2+ 1 mM Bos taurus
7.1.1.2 Mn2+ 1 mM Bos taurus
7.1.1.2 Ni2+ 1 mM, potent inhibitor Bos taurus
7.1.1.2 Zn2+ pH-dependent potent inhibitor, IC50: 0.01-0.05 mM at pH 7.5, depending on the enzyme state, Zn2+ does not inhibit NADH oxidation or intramolecular electron transfer, so it probably inhibits either proton transfer to bound quinone or proton translocation. Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrial membrane
-
 Bos taurus 31966
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + decylubiquinone
-
 Bos taurus NAD+ + decylubiquinol
-
 ?
7.1.1.2 NADH + hexaamineruthenium(III) chloride
-
 Bos taurus NAD+ + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Bos taurus
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 0.01 0.05 pH-dependent potent inhibitor, IC50: 0.01-0.05 mM at pH 7.5, depending on the enzyme state, Zn2+ does not inhibit NADH oxidation or intramolecular electron transfer, so it probably inhibits either proton transfer to bound quinone or proton translocation. Bos taurus Zn2+