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Literature summary extracted from
- Inhibition of heme oxygenase-1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice (2007), Int. J. Cancer, 120, 500-505.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | cobalt protoporphyrin IX | 1 mg/kg, 5.9fold increase of activity | Mus musculus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.18 | zinc protoporphyrin IX | 0.005 mg/kg, 82% inhibition | Mus musculus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.18 | lung cancer cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.18 | heme + electron donor + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.18 | heme oxygenase-1 | - |
Mus musculus |
| 1.14.14.18 | HO-1 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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