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Literature summary extracted from

  • Zhu, W.J.; Li, M.; Wang, X.Y.
    Chemical modification studies on arginine kinase: Essential cysteine and arginine residues at the active site (2007), Int. J. Biol. Macromol., 41, 564-571.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.3.3 ATP about 80% of the activity formerly inhibited by phenylglyoxal is retained by incubating with 20 mM ATP Locusta migratoria manilensis
2.7.3.3 dithiothreitol once treated with 5,5'-dithiobis-2-nitrobenzoic acid, the enzyme activity can be recovered more than 95% after incubation for 20 min with 0.15 mM dithiothreitol Locusta migratoria manilensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.3.3 5,5'-dithiobis-2-nitrobenzoic acid
-
 Locusta migratoria manilensis
2.7.3.3 DTNB the arginine kinase modified by DTNB can be fully reactivated by dithiothreitol in a monophasic kinetic course. This reactivation can be slowed down in the presence of ATP, suggesting that the essential Cys is located near the ATP binding site Locusta migratoria manilensis
2.7.3.3 Phenylglyoxal the enzyme loses 84.7% of its initial activity after incubation for 90 min with 0.0009 mM phenyllyoxal Locusta migratoria manilensis

Organism

EC Number Organism UniProt Comment Textmining
2.7.3.3 Locusta migratoria manilensis
-
-
-

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.7.3.3 the arginine kinase modified by DTNB can be fully reactivated by dithiothreitol in a monophasic kinetic course Locusta migratoria manilensis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.3.3 muscle
-
 Locusta migratoria manilensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.3.3 ATP + L-Arg
-
 Locusta migratoria manilensis ADP + Nomega-phospho-L-Arg
-
 r