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Literature summary extracted from

  • Temmink, O.H.; de Bruin, M.; Turksma, A.W.; Cricca, S.; Laan, A.C.; Peters, G.J.
    Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines (2007), Int. J. Biochem. Cell Biol., 39, 565-575.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.3 expressed in Colo-320TP1 and C26A cells Homo sapiens
2.4.2.4 expressed in Colo-320TP1 and C26A cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 5-benzylacyclouridine
-
 Homo sapiens
2.4.2.4 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Homo sapiens
-
-
-
2.4.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 Colo-320 cell
-
 Homo sapiens
-
2.4.2.3 colonic cancer cell
-
 Homo sapiens
-
2.4.2.3 HaCaT cell
-
 Homo sapiens
-
2.4.2.3 SW-1398 cell
-
 Homo sapiens
-
2.4.2.3 SW-948 cell
-
 Homo sapiens
-
2.4.2.4 Colo-320 cell
-
 Homo sapiens
-
2.4.2.4 colonic cancer cell
-
 Homo sapiens
-
2.4.2.4 HaCaT cell
-
 Homo sapiens
-
2.4.2.4 SW-1398 cell
-
 Homo sapiens
-
2.4.2.4 SW-948 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 5'-deoxy-5-fluorouridine + alpha-D-ribose 1-phosphate
-
 Homo sapiens 5'-deoxy-5-fluorouridine + phosphate
-
 ?
2.4.2.3 5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxy-D-ribose-1-phosphate also accepts 2'-deoxypyrimidine nucleosides in higher organisms r
2.4.2.3 5-fluorouracil + alpha-D-ribose 1-phosphate
-
 Homo sapiens 5-fluorouridine + phosphate
-
 ?
2.4.2.3 5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + alpha-D-ribose 1-phosphate
-
 r
2.4.2.4 5-fluoro-2'-deoxyuridine + phosphate
-
 Homo sapiens 5-fluorouracil + 2-deoxy-D-ribose 1-phosphate
-
 ?
2.4.2.4 5-fluorouridine + phosphate
-
 Homo sapiens 5-fluorouracil + D-ribose 1-phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.3 0.000098
-
 5-benzylacyclouridine in 50 mM Tris, 1 mM EDTA, pH 7.4, at 37°C Homo sapiens
2.4.2.4 0.017
-
 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride in 50 mM Tris, 1 mM EDTA, pH 7.4, at 37°C Homo sapiens