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Literature summary extracted from

  • Behling-Kelly, E.; McClenahan, D.; Kim, K.S.; Czuprynski, C.J.
    Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance (2007), Infect. Immun., 75, 4572-4581.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 additional information tumor necrosis factor-alpha induces enzyme activity in vivo Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 ML-7
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + light chain myosin II Bos taurus causes endothelial contraction ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 additional information Bos taurus infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 brain
-
 Bos taurus
-
2.7.11.18 brain endothelium cell line a SV40-infected endothelial cell line Bos taurus
-
2.7.11.18 central nervous system
-
 Bos taurus
-
2.7.11.18 endothelial cell brain Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + light chain myosin II
-
 Bos taurus ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 ATP + light chain myosin II causes endothelial contraction Bos taurus ADP + phosphorylated light chain myosin II
-
 ?
2.7.11.18 additional information infection of brain endothelial cells with Haemophilus somnus causes alterations in brain endothelial cell and blood-brain barrier integrity and causes inflammation involving the enzyme, which acts in rapid cytoskeletal rearrangement, overview Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Bos taurus
2.7.11.18 myosin light-chain kinase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Bos taurus