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Literature summary extracted from

  • Petzold, E.W.; Himmelreich, U.; Mylonakis, E.; Rude, T.; Toffaletti, D.; Cox, G.M.; Miller, J.L.; Perfect, J.R.
    Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans (2006), Infect. Immun., 74, 5877-5887.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.15 UDP-alpha-D-glucose + D-glucose 6-phosphate Cryptococcus neoformans var. grubii both TPS1 and TPS2 are required for high-temperature (37°C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of trehalose-6-phosphate, which makes this enzyme a fungicidal target UDP + alpha,alpha-trehalose 6-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.15 Cryptococcus neoformans var. grubii Q6IVK9
-
-
3.1.3.12 Cryptococcus neoformans Q059G6
-
-
3.1.3.12 Cryptococcus neoformans H99 Q059G6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.15 UDP-alpha-D-glucose + D-glucose 6-phosphate
-
 Cryptococcus neoformans var. grubii UDP + alpha,alpha-trehalose 6-phosphate
-
 ?
2.4.1.15 UDP-alpha-D-glucose + D-glucose 6-phosphate both TPS1 and TPS2 are required for high-temperature (37°C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of trehalose-6-phosphate, which makes this enzyme a fungicidal target Cryptococcus neoformans var. grubii UDP + alpha,alpha-trehalose 6-phosphate
-
 ?
3.1.3.12 trehalose 6-phosphate + H2O
-
 Cryptococcus neoformans trehalose + phosphate
-
 ?
3.1.3.12 trehalose 6-phosphate + H2O
-
 Cryptococcus neoformans H99 trehalose + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.15 TPS1
-
 Cryptococcus neoformans var. grubii
3.1.3.12 T6P phosphatase
-
 Cryptococcus neoformans
3.1.3.12 TPS2
-
 Cryptococcus neoformans
3.1.3.12 trehalose-6-phosphate phosphatase
-
 Cryptococcus neoformans