BRENDA - Enzyme Database

Unexpected basis for impaired Glc3Man9GlcNAc2-P-P-dolichol biosynthesis by elevated expression of Glcnac-1-p transferase

Gao, N.; Shang, J.; Lehrman, M.A.; Glycobiology 18, 125-134 (2007)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.15
GDP-mannose
5 residues of mannose from GDP-mannose
Mesocricetus auratus
2.7.8.15
tunicamycin
-
Mesocricetus auratus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.15
microsome
microsomal membranes
Cricetulus griseus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.8.15
Cricetulus griseus
-
-
-
2.7.8.15
Mesocricetus auratus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.15
CHO-K1 cell
-
Cricetulus griseus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.15
additional information
overexpression of GPT in CHO-K1 cells does not go along with accumulation of intermediate Man5GlcNAc2-diphosphodolichol because of alteration of levels of oligosaccharide-diphosphodolichol and monosaccharide-phosphodolichol or through GPT enzymatic activity and excessive dolichyl phosphate consumption but rather may interfere with utilization of mannose- and glucosephosphodolichol
673891
Cricetulus griseus
?
-
-
-
-
2.7.8.15
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
673891
Mesocricetus auratus
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
2.7.8.15
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
673891
Cricetulus griseus
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
initiating subsequent synthesis of Glc3Man9GlcNAc2-diphosphodolichol
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.8.15
GDP-mannose
5 residues of mannose from GDP-mannose
Mesocricetus auratus
2.7.8.15
tunicamycin
-
Mesocricetus auratus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.8.15
microsome
microsomal membranes
Cricetulus griseus
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.8.15
CHO-K1 cell
-
Cricetulus griseus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.8.15
additional information
overexpression of GPT in CHO-K1 cells does not go along with accumulation of intermediate Man5GlcNAc2-diphosphodolichol because of alteration of levels of oligosaccharide-diphosphodolichol and monosaccharide-phosphodolichol or through GPT enzymatic activity and excessive dolichyl phosphate consumption but rather may interfere with utilization of mannose- and glucosephosphodolichol
673891
Cricetulus griseus
?
-
-
-
-
2.7.8.15
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
673891
Mesocricetus auratus
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
-
-
?
2.7.8.15
UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate
-
673891
Cricetulus griseus
UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
initiating subsequent synthesis of Glc3Man9GlcNAc2-diphosphodolichol
-
-
?