Literature summary extracted from

Gao, N.; Shang, J.; Lehrman, M.A.
Unexpected basis for impaired Glc3Man9GlcNAc2-P-P-dolichol biosynthesis by elevated expression of Glcnac-1-p transferase (2007), Glycobiology, 18, 125-134.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.8.15	GDP-mannose	5 residues of mannose from GDP-mannose	Mesocricetus auratus
2.7.8.15	tunicamycin	-	Mesocricetus auratus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.7.8.15	microsome	microsomal membranes	Cricetulus griseus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.8.15	Cricetulus griseus	-	-	-
2.7.8.15	Mesocricetus auratus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.8.15	CHO-K1 cell	-	Cricetulus griseus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.8.15	additional information	overexpression of GPT in CHO-K1 cells does not go along with accumulation of intermediate Man5GlcNAc2-diphosphodolichol because of alteration of levels of oligosaccharide-diphosphodolichol and monosaccharide-phosphodolichol or through GPT enzymatic activity and excessive dolichyl phosphate consumption but rather may interfere with utilization of mannose- and glucosephosphodolichol	Cricetulus griseus	?	-	?
2.7.8.15	UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate	-	Mesocricetus auratus	UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol	-	?
2.7.8.15	UDP-N-acetyl-alpha-D-glucosamine + dolichyl phosphate	-	Cricetulus griseus	UMP + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol	initiating subsequent synthesis of Glc3Man9GlcNAc2-diphosphodolichol	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.8.15	GlcNAc-1-P transferase	-	Cricetulus griseus
2.7.8.15	GlcNAc-1-P transferase	-	Mesocricetus auratus
2.7.8.15	GPT	-	Cricetulus griseus
2.7.8.15	GPT	-	Mesocricetus auratus

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Release 2023.1 (January 2023)