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Literature summary extracted from

  • Hanaoka, R.; Katayama, S.; Dawid, I.B.; Kawahara, A.
    Characterization of the heme synthesis enzyme coproporphyrinogen oxidase (CPO) in zebrafish erythrogenesis (2006), Genes Cells, 11, 293-303.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.3.3 medicine function of CPO in heme biosynthesis is apparently conserved between zebrafish and human, suggesting that CPO-MO-injected zebrafish embryos might be a useful in vivo assay system to measure the biological activity of human CPO mutations Danio rerio

Protein Variants

EC Number Protein Variants Comment Organism
1.3.3.3 additional information knockdown of zebrafish CPO using anti-sense morpholinos leads to a significant suppression of hemoglobin production without apparent reduction of blood cells, injection of human CPO RNA, but not a mutant CPO RNA similar to a mutant responsible for a hereditary coproporphyria, restores hemoglobin production in the CPO-MO-injected embryos, expression of CPO in the ICM is severely suppressed in both vlad tepes/gata1 mutants and in biklf-MO-injected embryos Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Danio rerio
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 zebrafish strain AB or Riken-Wako
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 embryo
-
 Danio rerio
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1.3.3.3 additional information intermediate cell mass Danio rerio
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Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 CPO
-
 Danio rerio