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Literature summary extracted from

  • Seo, Y.K.; Chung, Y.T.; Kim, S.; Echchgadda, I.; Song, C.S.; Chatterjee, B.
    Xenobiotic- and vitamin D-responsive induction of the steroid/bile acid-sulfotransferase Sult2A1 in young and old mice: the role of a gene enhancer in the liver chromatin (2007), Gene, 386, 218-223.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.14 pregnenolone-16alpha-carbonitrile aging does not change the induction of enzyme by synthetic steroid pregnenolone-16alpha-carbonitrile Mus musculus
2.8.2.14 vitamin D3 aging does not change the induction of enzyme by hormonally active vitamin D3 Mus musculus
2.8.2.15 additional information induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN Mus musculus

Application

EC Number Application Comment Organism
2.8.2.14 medicine aging does not influence the response to the hormonal and xenobiotic signaling for enzyme Sult2A1 induction Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.15 expression analysis of SULT2A1, induction of SULT2A1 expression by xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR, aging has no effect on the activity of an IR0 enhancer in the Sult2A1 chromatin to recruit VDR, RXR-alpha, and PXR in mice injected with D3 or PCN Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.15 nucleus
-
 Mus musculus 5634
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.15 additional information Mus musculus Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility, deviant expression of steroid- and xenobiotic-metabolizing enzymes due to metabolic stress causes severe health problems including accelerated aging, and increased expression of these enzymes is associated with extended longevity, overview, xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR regulating steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, are involved in enzyme regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.14 Mus musculus
-
 aging does not influence the response to the hormonal and xenobiotic signaling for enzyme Sult2A1 induction
-
2.8.2.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.15 liver of 4-month- and 20-month-old mice, SULT2A1 expression analysis, overview Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 additional information Sult2A1 converts bile acids, steroids and a number of drugs to the corresponding sulfated metabolites, which are readily eliminated from the body due to increased water solubility, deviant expression of steroid- and xenobiotic-metabolizing enzymes due to metabolic stress causes severe health problems including accelerated aging, and increased expression of these enzymes is associated with extended longevity, overview, xenobiotic-activated nuclear receptors pregnane X receptor PXR, constitutive androstane receptor CAR, and the vitamin D3-activated nuclear receptor VDR regulating steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, are involved in enzyme regulation, overview Mus musculus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 steroid/bile acid-sulfotransferase
-
 Mus musculus
2.8.2.15 SULT2A1
-
 Mus musculus