Literature summary extracted from

Quint, P.; Reutzel, R.; Mikulski, R.; McKenna, R.; Silverman, D.N.
Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation (2006), Free Radic. Biol. Med., 40, 453-458.

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
1.15.1.1	comparison of native protein and enzyme nitrated at active site residue Y34, no significant change in conformation upon nitration	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.15.1.1	peroxynitrite	almost complete inhibition via nitration of active-site residue Y34, no significant change in conformation upon nitration. Inhibition occurs either through a steric effect of 3-nitrotyrosine 34 that impedes substrate binding or through an electrostatic effect of the nitro group	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.15.1.1	Homo sapiens	P04179	MnSOD	-

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Release 2023.1 (January 2023)