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Literature summary extracted from

  • Sillero, M.A.; de Diego, A.; Silles, E.; Perez-Zuniga, F.; Sillero, A.
    Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase (2006), FEBS Lett., 580, 5723-5727.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.5.1.3 0.26
-
 methylenebisphosphonate
-
 Tequatrovirus T4
6.5.1.3 0.54
-
 clodronate
-
 Tequatrovirus T4
6.5.1.3 4.3
-
 etidronate
-
 Tequatrovirus T4

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.3 Tequatrovirus T4
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.3 ATP + clodronate
-
 Tequatrovirus T4 adenosine 5'-(beta,gamma-dichloromethylenetriphosphate) + ?
-
 ?
6.5.1.3 ATP + etidronate weak activity Tequatrovirus T4 ?
-
 ?
6.5.1.3 ATP + methylenebisphosphonate
-
 Tequatrovirus T4 adenosine 5'-(beta,gamma-methylenetriphosphate) + ?
-
 ?
6.5.1.3 additional information no activity with alendronate nor pamidronate Tequatrovirus T4 ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.5.1.3 0.028
-
 etidronate
-
 Tequatrovirus T4
6.5.1.3 0.28
-
 methylenebisphosphonate
-
 Tequatrovirus T4
6.5.1.3 0.29
-
 clodronate
-
 Tequatrovirus T4