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Literature summary extracted from

  • Tahara, E.B.; Barros, M.H.; Oliveira, G.A.; Netto, L.E.; Kowaltowski, A.J.
    Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging (2007), FASEB J., 21, 274-283.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.8.1.4 medicine dihydrolipoyl dehydrogenase is an important source of reactive oxygen species leading to life span limitation Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
1.8.1.4 additional information deletion of the LPD1 gene prevents oxidative stress in npt1DELTA and bna6DELTA mutants Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.4 additional information inhibited by caloric restriction Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.4 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 dihydrolipoamide + NAD+
-
 Saccharomyces cerevisiae lipoamide + NADH + H+
-
 ?
1.8.1.4 O2 + NADH + H+
-
 Saccharomyces cerevisiae H2O2 + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.4 dihydrolipoamide dehydrogenase
-
 Saccharomyces cerevisiae
1.8.1.4 LPD1
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 NAD+
-
 Saccharomyces cerevisiae
1.8.1.4 NADH
-
 Saccharomyces cerevisiae