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Literature summary extracted from

  • Boonyapiwat, B.; Panagopoulos, P.; Jones, H.; Mitchell, S.C.; Forbes, B.; Steventon, G.B.
    Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine in HepG2 cells (2005), Drug Metabol. Drug Interact., 21, 1-18.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.1 7.14
-
 L-phenylalanine
-
 Homo sapiens
1.14.16.1 25.24
-
 S-carboxymethyl-L-cysteine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.1 L-phenylalanine + tetrahydrobiopterin + O2 Homo sapiens modelling of cellular regulation L-tyrosine + 4a-hydroxy-tetrahydrobiopterin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.1 Hep-G2 cell
-
 Homo sapiens
-
1.14.16.1 hepatocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.1 L-phenylalanine + tetrahydrobiopterin + O2
-
 Homo sapiens L-tyrosine + 4a-hydroxy-tetrahydrobiopterin
-
 ?
1.14.16.1 L-phenylalanine + tetrahydrobiopterin + O2 modelling of cellular regulation Homo sapiens L-tyrosine + 4a-hydroxy-tetrahydrobiopterin
-
 ?
1.14.16.1 S-carboxymethyl-L-cysteine + tetrahydrobiopterin + O2 conversion to the (S)-sulfoxide Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.1 PAH
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.1 tetrahydrobiopterin
-
 Homo sapiens