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Literature summary extracted from

  • Furimsky, A.M.; Green, C.E.; Hunt Sharp, L.E.; Catz, P.; Adjei, A.A.; Parman, T.; Kapetanovic, I.M.; Weinshilboum, R.M.; Iyer, L.V.
    Effect of resveratrol on 17{beta}-estradiol sulfation by human hepatic and jejunal S9 and recombinant SULT1E1 (2008), Drug Metab. Dispos., 36, 129-136.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.1 R213H polymorphism of SULT1A1, overview Homo sapiens
2.8.2.1 R213H polymorphism of SULT1A1, the mutant variant is termed SULT1A1*2 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 additional information no effect by 0.1-1.0% v/v ethanol Homo sapiens
2.8.2.4 resveratrol inhibits estradiol sulfonation, phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.4 0.000007
-
 ethinyl estradiol pH 7.4, SULT1E1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + estradiol Homo sapiens the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity adenosine 3',5'-bisphosphate + estradiol sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estradiol Homo sapiens
-
 adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
2.8.2.4 additional information Homo sapiens phytoestrogens can potentially alter the homeostasis of estrogen levels ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 female and male
-
2.8.2.4 Homo sapiens
-
 female and male
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 commercial preparation recombinant SULT1A1 expressed in insect Sf9 cells Homo sapiens
-
2.8.2.1 intestine
-
 Homo sapiens
-
2.8.2.1 jejunum S9 fractions Homo sapiens
-
2.8.2.1 liver S9 fractions Homo sapiens
-
2.8.2.1 additional information analysis of tissue specific expression of the enzyme, overview Homo sapiens
-
2.8.2.4 commercial preparation recombinant SULT1E1 expressed in insect Sf9 cells Homo sapiens
-
2.8.2.4 intestine
-
 Homo sapiens
-
2.8.2.4 jejunum S9 fractions Homo sapiens
-
2.8.2.4 liver S9 fractions Homo sapiens
-
2.8.2.4 additional information analysis of tissue specific expression of the enzyme, overview Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.1 0.0000000009
-
 reaction of EC 2.8.2.4, estrone sulfotransferase, SULT1A2 Homo sapiens
2.8.2.1 0.0000000023
-
 reaction of EC 2.8.2.4, estrone sulfotransferase, SULT1A1*2 Homo sapiens
2.8.2.4 0.0000000049
-
 recombinant SULT1E1 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + estradiol the enzyme also performs the reaction of EC 2.8.2.4, estrone sulfotransferase, with low activity Homo sapiens adenosine 3',5'-bisphosphate + estradiol sulfate
-
 ?
2.8.2.4 3'-phopshoadenylyl sulfate + resveratrol i.e. 3,5,4'-trihydroxystilbene, a phytoestrogen with mixed estrogen agonist/antagonist properties developed as a chemopreventive agent, interaction of resveratrol with 17beta-estradiol, overview Homo sapiens adenosine 3',5'-bisphosphate + resveratrol 3-O-sulfate + resveratrol 4'-O-sulfate + resveratrol 3,4'-O-disulfate three different sulfate products, product identification by NMR, overview ?
2.8.2.4 3'-phosphoadenylyl sulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estradiol isozyme SULT1E1 is specific for estradiol sulfonation, interaction of resveratrol with 17beta-estradiol, overview Homo sapiens adenosine 3',5'-bisphosphate + estradiol 3-sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + ethinyl estradiol a synthetic oral contraceptive, low activity Homo sapiens adenosine 3',5'-bisphosphate + ethinyl estradiol 3-sulfate
-
 ?
2.8.2.4 additional information phytoestrogens can potentially alter the homeostasis of estrogen levels Homo sapiens ?
-
 ?
2.8.2.4 additional information the reaction is also performed by the phenol sulfotranferase, EC 2.8.2.1, but with lower activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A1
-
 Homo sapiens
2.8.2.1 SULT1A1*2
-
 Homo sapiens
2.8.2.1 SULT1A2
-
 Homo sapiens
2.8.2.4 EST
-
 Homo sapiens
2.8.2.4 estrogen sulfotransferase
-
 Homo sapiens
2.8.2.4 SULT1E1
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 7.4
-
 assay at Homo sapiens
2.8.2.4 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.4 0.0006
-
 resveratrol pH 7.4, jejunum extract, inhibition of estradiol sulfonation Homo sapiens
2.8.2.4 0.0011
-
 resveratrol pH 7.4, liver extract, inhibition of estradiol sulfonation Homo sapiens
2.8.2.4 0.0023
-
 resveratrol pH 7.4, recombinant SULT1E1, inhibition of estradiol sulfonation Homo sapiens