Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nobecourt, E.; Davies, M.J.; Brown, B.E.; Curtiss, L.K.; Bonnet, D.J.; Charlton, F.; Januszewski, A.S.; Jenkins, A.J.; Barter, P.J.; Rye, K.A.
    The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase (2007), Diabetologia, 50, 643-653.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I glycation affects the structure of apoA-I and its ability to activate the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 glycated discoidal (A-I)rHDL after modification of lipid-free apoA-I arginine, lysine and tryptophan residues by glucose Homo sapiens
2.3.1.43 unesterified cholesterol-(apo lipoprotein A-I-)HDL the unesterified cholesterol is deuterium-labeled Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 additional information Homo sapiens key enzyme in reverse cholesterol transport ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.43 native enzyme from plasma to homogeneity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information key enzyme in reverse cholesterol transport Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin:cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.43 additional information
-
 additional information inhibition kinetics Homo sapiens