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Literature summary extracted from

  • Kuhajda, F.P.; Ronnett, G.V.
    Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity (2007), Curr. Opin. Investig. Drugs, 8, 312-317.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.21 C-75 i.e. 3-carboxy-4-alkyl-2-methylenebutyrolactone, physiologic enzyme stimulation, regulatory effects, overview Homo sapiens
2.3.1.21 C-75 i.e. 3-carboxy-4-alkyl-2-methylenebutyrolactone, physiologic enzyme stimulation, the stimulation reduces food consumption and weight, regulatory effects, overview Rattus norvegicus

Application

EC Number Application Comment Organism
2.3.1.21 medicine enzyme inhibitors are used to shift the heart's reliance away from fatty acid oxidation to glucose as energy source to increase cardiac efficiency, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.21 etomoxir
-
 Homo sapiens
2.3.1.21 malonyl-CoA has a regulatory role in vivo Homo sapiens
2.3.1.21 malonyl-CoA has a regulatory role in vivo Rattus norvegicus
2.3.1.21 additional information enzyme inhibitors are used to shift the heart's reliance away from fatty acid oxidation to glucose as energy source to increase cardiac efficiency, overview Homo sapiens
2.3.1.21 oxfenicine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.21 mitochondrial outer membrane
-
 Homo sapiens 5741
-
2.3.1.21 mitochondrial outer membrane
-
 Rattus norvegicus 5741
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.21 88200
-
 x * 88200, isozymes L-CPT1 and M-CPT1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.21 additional information Rattus norvegicus the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, inhibition of fatty acid oxidation increases food intake, overview ?
-
 ?
2.3.1.21 additional information Homo sapiens the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, overview ?
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.21 Homo sapiens
-
 isozymes L-CPT1 and M-CPT1
-
2.3.1.21 Rattus norvegicus
-
 isozymes L-CPT1 and M-CPT1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.21 liver isozyme L-CPT-1 Homo sapiens
-
2.3.1.21 liver isozyme L-CPT-1 Rattus norvegicus
-
2.3.1.21 muscle isozyme M-CPT-1 Homo sapiens
-
2.3.1.21 muscle isozyme M-CPT-1 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.21 additional information the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, inhibition of fatty acid oxidation increases food intake, overview Rattus norvegicus ?
-
 ?
2.3.1.21 additional information the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, overview Homo sapiens ?
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?
2.3.1.21 palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.21 ? x * 88200, isozymes L-CPT1 and M-CPT1 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.21 carnitine palmitoyltransferase-1
-
 Homo sapiens
2.3.1.21 carnitine palmitoyltransferase-1
-
 Rattus norvegicus
2.3.1.21 CPT-1
-
 Homo sapiens
2.3.1.21 CPT-1
-
 Rattus norvegicus