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Literature summary extracted from

  • Kallay, E.; Bises, G.; Bajna, E.; Bieglmayer, C.; Gerdenitsch, W.; Steffan, I.; Kato, S.; Armbrecht, H.J.; Cross, H.S.
    Colon-specific regulation of vitamin D hydroxylases - a possible approach for tumor prevention (2005), Carcinogenesis, 26, 1581-1589.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.18 expression of vitamin D hydroxylases in the VDR-/- mouse model, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.18 additional information expression of vitamin D hydroxylases in the VDR-/- mouse model, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2 Homo sapiens 1,25-dihydroxyvitamin D3 (1,25-D3) is a key determinant of calcium homeostasis, cell proliferation and differentiation, calcium and vitamin D might have a protective function against colorectal tumor pathogenesis, overview 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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 ?
1.14.15.18 additional information Homo sapiens colonic and renal vitamin D hydroxylases are regulated independently ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.18 Caco-2 cell
-
 Homo sapiens
-
1.14.15.18 colon tissue-specific enzyme regulation Homo sapiens
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1.14.15.18 additional information tissue-specific expression analysis, colonic and renal vitamin D hydroxylases are regulated independently, while low dietary calcium does not affect colonic expression of vitamin D receptor, VDR, or 25-hydroxyvitamin D3 1alpha-hydroxylase, it influences their renal expression by elevating CYP27B1 expression and reducing VDR and 25-hydroxyvitamin D3 24-hydroxylase expression, overview Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.18 25-hydroxyvitamin D + NADPH + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 25-hydroxyvitamin D + NADPH + O2 1,25-dihydroxyvitamin D3 (1,25-D3) is a key determinant of calcium homeostasis, cell proliferation and differentiation, calcium and vitamin D might have a protective function against colorectal tumor pathogenesis, overview Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
1.14.15.18 additional information colonic and renal vitamin D hydroxylases are regulated independently Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.18 vitamin D hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.18 NADPH
-
 Homo sapiens