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Literature summary extracted from

  • Meng, L.H.; Shankavaram, U.; Chen, C.; Agama, K.; Fu, H.Q.; Gonzalez, F.J.; Weinstein, J.; Pommier, Y.
    Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX (2006), Cancer Res., 66, 9656-9664.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.1 additional information 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one induces the expression of SULT1A1 via the aryl hydrocarbon receptor, AhR, signaling pathway, mechanism, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.1 additional information downregulation of SULT1A1 by specific siRNA, transfection of SULT1A1 into MDA-MB-231 cells restores formation of DNA-protein cross-links and histone gamma-H2AX foci in response to aminoflavone Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 apigenin antagonizes aminoflavone by inhibiting SULT1A1 Homo sapiens
2.8.2.1 daidzein antagonizes aminoflavone by inhibiting SULT1A1 Homo sapiens
2.8.2.1 genistein antagonizes aminoflavone by inhibiting SULT1A1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one Homo sapiens i.e. aminoflavone, diaminoflavone analogues with potent growth-inhibitory activity against human breast and renal cancer cells in vitro and antitumor activity in mice bearing human tumor xenografts, aminoflavone binds to DNA in tumor cells and induces DNA-protein cross-links adenosine 3',5'-bisphosphate + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P50225
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 MCF-7 cell
-
 Homo sapiens
-
2.8.2.1 MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one i.e. aminoflavone, diaminoflavone analogues with potent growth-inhibitory activity against human breast and renal cancer cells in vitro and antitumor activity in mice bearing human tumor xenografts, aminoflavone binds to DNA in tumor cells and induces DNA-protein cross-links Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.1 3'-phosphoadenylyl sulfate + 5-amino-2-(4-amino-3-fluorophenyl)-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one i.e. aminoflavone Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 7.4
-
 assay at Homo sapiens