Literature summary extracted from

Elbekai, R.H.; Duke, J.; El-Kadi, A.O.
Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+) (2007), Cancer Lett., 246, 54-62.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.6.5.2	ascorbic acid	superinduction of the enzyme induction by As3+	Mus musculus

Application

EC Number	Application	Comment	Organism
1.6.5.2	medicine	ascorbic acid may potentiate the therapeutic efficacy of As3+ in treatment of acute promyelotic leukemia by enhancing the expression of enzyme together with heme oxygenase-1 and glutathione S-transferase Ya	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.6.5.2	Cr6+	decrease of enzyme mRNA level together with heme oxygenase-1 and glutathione S-transferase Ya	Mus musculus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.6.5.2	As3+	induction of enzyme together with heme oxygenase-1 and glutathione S-transferase Ya	Mus musculus
1.6.5.2	Cd2+	induction of enzyme together with heme oxygenase-1 and glutathione S-transferase Ya	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.5.2	Mus musculus	-	isoform Nqo1	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.5.2	Hepa-1c1c7 cell	hepatoma cell line	Mus musculus	-

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Release 2023.1 (January 2023)